Project structure and participants
The project consists of 8 tasks (i.e. work packages). Three focus on vital support activities, such as project management (WP1), communication, dissemination and training (WP2) and stakeholder engagement and co-design (WP8), while five others develop R&D activities. Through these, Bioindustry 4.0 will deliver results that underpin new research infrastructure services:
WP1: Communication and project management
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INRAE is a public research institute working for the coherent and sustainable development of agriculture, food and the environment. |
INRAE Transfert is a technology transfer and project engineering company that promotes innovations in food, agriculture, and the environment. |
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WP2: Dissemination, Communication and Exploitation
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INRAE Transfert is a technology transfer and project engineering company that promotes innovations in food, agriculture, and the environment. |
Biofaction is an interdisciplinary research and science communication company working with emerging sciences, technologies, art, and design. |
Consiglio Nazionale delle Ricerche, CNR is the largest research council in Italy. As a public organisation, its remit is to support scientific and technological research. |
VITO is an independent Flemish research organisation in the area of cleantech and sustainable development. Our goal? To accelerate the transition to a sustainable world. |
WP3: Use Cases
Drawing on several bioreaction use cases (i.e. different bioreactor configurations involving different microorganisms and different target products), data will be generated to develop digital services (WP3) such as digital shadows (i.e. a digital representation of the physical bioreactor that can be manually fed with data pertaining to operation of the physical bioreactor). Users of the digital shadows can learn more bioreactor operations and identify strategies to improve bioreactor performance. Ultimately, digital shadows will form the basis of a decision support system for bioprocess design.
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INRAE is a public research institute working for the coherent and sustainable development of agriculture, food and the environment. |
VTT is a visionary research, development and innovation partner and one of the leading research organisations in Europe. |
Wageningen University & Research is a university and research centre in the Netherlands that focusses specifically on the theme ‘healthy food and living environments’. |
With more than 47,000 students enrolled in 144 study programs, RWTH Aachen is the largest technical university in Germany. |
WP4: Novel PAT instruments for in-process bioprocess monitoring
Developing novel in-line sensors (commonly called PAT or process analytical technology devices), work in WP4 aims to provide key elements for real-time monitoring of bioreactions. Once developed, these instruments will be deployed, extensively tested (including the simultaneous use of multiple devices), and coupled to digital twins (WP4):
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VTT is a visionary research, development and innovation partner and one of the leading research organisations in Europe. |
Timegated Technology offers real-time bioprocess monitoring and control, improved process and product quality, and faster time-to-market for biopharmaceuticals. |
VITO is an independent Flemish research organisation in the area of cleantech and sustainable development. Our goal? To accelerate the transition to a sustainable world. |
With more than 47,000 students enrolled in 144 study programs, RWTH Aachen is the largest technical university in Germany. |
WP5: Digital Twins
Work in WP5 deals with the development of digital shadows and digital twins. Challenges to be tackled include the development of suitable scaffolds for physical models, the integration of biological data, and the deployment of AI approaches , such as deep learning and unsupervised model reduction, using convolutional neural networks. The overarching aim is to devise digital tools for bioprocess replication and validation, for decision support and knowledge extraction, and for autonomous real-time control of bioprocesses:
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National Technical University of Athens (NTUA) is the oldest and most prestigious educational institution of Greece in the field of technology. |
In collaboration with Process Systems Enterprise (PSE), Siemens is moving a step closer to Industry 4.0 and creating ideal conditions for digitalized plant operation in the process industry. |
Wageningen University & Research is a university and research centre in the Netherlands that focusses specifically on the theme ‘healthy food and living environments’. |
With more than 47,000 students enrolled in 144 study programs, RWTH Aachen is the largest technical university in Germany. |
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Athena Research Center conducts outstanding research in Informatics and Computational Sciences ensuring this research has an impact on society. |
SYMBIOLABS follows an interdisciplinary approach to support industries and policy makers in their transition to the Circular Economy, providing Circular Intelligence solutions. |
The Institut National des Sciences Appliquées de Toulouse is a French grande école of engineering, under the authority of the French Ministry of Education and Research. |
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WP6: Digital tools to expand industrial exploitation of microbial biodiversity
Focusing on the enhancement of the innovation potential of microbial culture collections, work in WP6 will adopt data-driven approaches to reach several goals. Crucially, one task will focus on creating a common data structure to empower interoperability between the data held in different collections. Other tasks will address the development of powerful querying approaches tailored to the needs of the industrial biotechnology sector and the enhancement of knowledge extraction using AI-based methods:
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The Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures GmbH is one of the largest bioresource centres and the most diverse collection worldwide. |
Westerdijk Fungal Biodiversity Institute maintains a world-renowned microbial biological resource centre of living fungi, yeasts and bacteria. |
Wageningen University & Research is a university and research centre in the Netherlands that focusses specifically on the theme ‘healthy food and living environments’. |
The University of Valencia is a public research university located in the city of Valencia, Spain. It is one of the oldest universities in Spain. |
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LifeGlimmer is providing solutions for the full research pipeline in bioinformatics, data integration, and systems biology. |
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Focusing on the enhancement of the innovation potential of microbial culture collections, work in WP6 will adopt data-driven approaches to reach several goals. Crucially, one task will focus on creating a common data structure to empower interoperability between the data held in different collections. Other tasks will address the development of powerful querying approaches tailored to the needs of the industrial biotechnology sector and the enhancement of knowledge extraction using AI-based methods:
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WP7: Tools for high-quality datasets
Considering that Bioindustry 4.0 heavily relies on the availability of good-quality data, pivotal work will be carried out to create a so-called data fabric (WP7). This is an architecture that integrates and manages data across different systems and computing environments. Its purpose is to generate high-quality data sets for AI-powered approaches. Moreover, work will lay the technical basis for the constitution of trusted data networks that will enable secure data sharing between consenting data owners:
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Wageningen University & Research is a university and research centre in the Netherlands that focusses specifically on the theme ‘healthy food and living environments’. |
BBMRI–ERIC is a European biobanking research infrastructure dedicated to providing researchers with the support they need to find new treatments. |
INRAE is a public research institute working for the coherent and sustainable development of agriculture, food and the environment. |
Newcastle University is a public research university based in Newcastle upon Tyne, North East England. |
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The University of Manchester is part of the prestigious Russell Group of universities and highly respected across the globe as a centre of teaching excellence and research innovation and discovery. |
The Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures GmbH is one of the largest bioresource centres and the most diverse collection worldwide. |
Athena Research Center conducts outstanding research in Informatics and Computational Sciences ensuring this research has an impact on society.
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The Fraunhofer Institute for Software and Systems Engineering ISST develops data space technologies for sovereign data exchange and builds pioneering data ecosystems with its partners.
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WP8: Stakeholder engagement
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Biofaction is an interdisciplinary research and science communication company working with emerging sciences, technologies, art, and design. |
Bioeconomy For Change is the reference network, specializing in the production and modification of biomass for food production and bio-based materials. |
The Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures GmbH is one of the largest bioresource centres and the most diverse collection worldwide. |
MIRRI is the pan-European distributed Research Infrastructure for the preservation, systematic investigation, provision and valorisation of microbial resources |
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BBMRI–ERIC is a European biobanking research infrastructure dedicated to providing researchers with the support they need to find new treatments. |
The Fraunhofer Institute for Software and Systems Engineering ISST develops data space technologies for sovereign data exchange and builds pioneering data ecosystems with its partners. |
The University of Koblenz-Landau is a young, medium-sized university with a pronounced research orientation within the thematic trias “LEARNING-SOCIETY-ENVIRONMENT”.
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